During periods of physical stress, such as intense weight lifting and running, the body can enter a catabolic state – that is a state in which muscle tissue is broken down. When this happens, supplementing with BCAAs – especially leucine and its derivatives ketoisocaproate (KIC) and hydroxymethylbutyrate (HMB) is very beneficial in reducing protein breakdown. 

• The only amino acids that are metabolised in the muscle, rather than in the liver 
• Help to maintain muscle tissue during periods of high stress or low calories 
• Serve as important fuel sources for skeletal muscle during periods of metabolic stress 
• Promote protein synthesis while suppressing protein catabolism 
• Serve as substrates for gluconeogenesis 
• Stimulate the production of, among other substances, L-alanine and L-glutamine 
• Help improve strength and endurance 
• Make you less susceptible to infections caused by the stress of exercise 
• Improve performance under extreme conditions, such as high altitude or heat 
• Considered essential amino acids because human beings cannot survive unless these amino acids are present in the diet